?aniline
aniline發(fā)音
英:['?n?li:n] 美:['?n?l?i:n]
英: 美:
aniline中文意思翻譯
adj. 苯胺的
n. 苯胺
aniline常見例句
1 、With triethylamine phosphoric acid/nickeloussulfate as catalyst,the N-phenyl malemide was prepared from aniline and maleic anhydride by two-step method.───以順酐和苯胺為原料,采用三乙胺/**酸/硫酸鎳為催化劑,通過兩步法制得N-苯基馬來酰亞胺。
2 、The electrochemical polymerization of aniline by cyclic voltammetric method at ultramicroelectrode is investigated.───本文對超微盤電極上苯胺的循環(huán)掃描伏安法電化學(xué)聚合進(jìn)行了研究。
3 、Metachromatic granules contain RNA and polyphosphates They are deeply stained with aniline dyes. They are characteristic features of the corynebacteria.───異染顆粒含RNA和多聚**酸鹽。用苯胺染料可濃染。是棒狀桿菌的特點(diǎn)。
4 、The electrochemical polymerization of aniline were carried out by using the cyclic voltmmetric method in the different protonic acid.───利用循環(huán)伏安方法在不同質(zhì)子酸摻雜下電化學(xué)聚合苯胺,并以聚合電量隨循環(huán)次數(shù)的變化測定苯胺電聚合的速率。
5 、Quinoline could be hydrogenated into tetrahydroquinoline, which would be cracked into pyridine, aniline and ammonia.───喹啉加氫生成四氫喹啉,四氫喹啉進(jìn)一步裂化轉(zhuǎn)化為吡啶、苯胺和氨。
6 、They said they're aniline derivatives, but they may have different names, so here's what you're looking for.─── 他們說是苯胺衍生物 但可能會有不同的名字 你要找的是這些
7 、Second method, p-fluoro aniline and chloroacetic chloride chloroacetyl chloride were used as initial materials and alkylation was carried out.───方法二以對氟苯胺和氯**氯為起始原料,然后進(jìn)行烷基化成環(huán)。
8 、When used as a base coat with color-leveling effect on aniline leather, it can be mixed with LIVAL COLOR VL dyes.───染色前封閉劑時,可與水混合或純原液,用布或海面均勻地稀薄地涂在表面,如是大面積應(yīng)用,也可用噴**。用海綿單獨(dú)用于破裂和多孔易滲皮革的產(chǎn)品。
9 、The results showed that the immobilized cyclodextrin adsorbed phenol and aniline mainly via physical adsorption,while adsorbed metal ions via chemical adsorption.───實驗結(jié)果表明:固載化環(huán)糊精對苯酚和苯胺的吸附主要是物理吸附,對金屬離子以化學(xué)吸附為主。
10 、A novel composite membrane has been developed in this paper.This membrane is prepared by polymerization technique from Aniline redox system.And PVC was used as supporting membrane.───本文提出用溶液相引發(fā)聚合的方法,以聚氯乙烯(PVC)為膜基,通過氧化劑,使苯胺氧化聚合,制成了新型復(fù)合膜。
11 、While, aniline enhanced the sorption capacity of TCB in the whole residual solution ranges of TCB in the preloading system.───對于改變共溶質(zhì)初始濃度的混合吸附體系,隨著共溶質(zhì)濃度的逐漸增大,1,4-二氯苯對1,2,4-三氯苯的抑制作用逐漸增強(qiáng),最終達(dá)到穩(wěn)定;
12 、The experiments have been performed that the carbon nanotubes in dispersion were coated with polyaniline by polymeration of the aniline in situ on the CNTs and there mwcnts were added into polypropylene.───摘要進(jìn)行了用苯氨單體在含有分散碳納米管的環(huán)境中發(fā)生聚合,使聚苯胺包覆碳納米管,然后把這些碳納米管添加到聚丙烯中的實驗。
13 、Full Aniline Oil Based Pull Up - Bearing all original marks and scars of the hide, the most natural of the available leathers.───全苯胺油涂飾皮料---這種皮料帶有動物皮革上所有的自然印記和疤痕,是現(xiàn)有的皮革中最天然的一種。
14 、Info:Motorbike leather and cordura glove Made in Aniline cowhide leather with black nylon cordura Foam ......───主要材質(zhì):真皮次要材質(zhì):尼龍/錦綸適用對象:男款式:分指手套
15 、Theree new kinds of reagent kits for determination of aniline in water have been developed:guaiacol reagent kits,8-hydroxy-quinoline reagent kits and 1-naphthol reagent kits.───本文篩選并研制出三種檢測水中苯胺類化合物的試劑盒:鄰甲氧基苯酚試劑盒、8-羥基喹啉試劑盒和1-萘酚試劑盒。
16 、A new method of variable-angle synchronous spectrofluorimetry has been developed for the simultaneous determination of phenol and aniline.───本文建立了苯酚和苯胺的同時可變角同步熒光分析法。
17 、Fig. 5 Variation of furfural calibration curves in aniline acetate colorometric method.───圖5醋酸苯胺比色法,糠醛標準校正線之變化。
18 、As for the mechanism of ozonation, so far only the aromatic intermediate by-products of aniline have been studied.───對于臭氧氧化的機(jī)理,目前僅研究了苯胺的芳香族中間產(chǎn)物
19 、With phosphato-tungstic acid as catalyst and phosphoric acid as dehydrant,N-phenylmaleimide was prepared from aniline and maleic anhydride by two-step method.The yield was 88.7% and the purity was 98.2%.───以順酐和苯胺為原料,**鎢酸作催化劑,**酸作脫水劑,采用兩步法制得N-苯基馬來酰亞胺,得到最佳反應(yīng)工藝條件,產(chǎn)品收率為88.7%,純度為98.2%(質(zhì)量分?jǐn)?shù))。
20 、At same time, we discovery that the addition of peptone to aniline minimal medium resulted in an acceleration of the aniline degradation rate, especially for strain AN4.───同時研究發(fā)現(xiàn)投加蛋白胨可以加速菌株對苯胺的代謝,在這一點(diǎn)上菌株AN4尤其明顯。
21 、This paper provided the way im which Aniline can be multi-electro-proymerized in the neutral medium solution.───本文給出了一種在中性介質(zhì)中,苯胺進(jìn)行多次掃描聚合的方法。
22 、To investigate the effect of Molybdenum on liver microsomal fraction aniline hydroxylase in rats,50 rats were randomly divided into 5 groups.───為研究鉬對大鼠肝微粒體中苯胺羥化酶的影響,將50只大鼠隨機(jī)分為5個組,4個試驗組每天分別灌服劑量為8。
23 、Li Jingfeng, 35, an electrician at an ethanol plant that abuts the aniline plant, said chemical detectors at his factory had gone off five or six times in the last month, forcing workers to evacuate.───李靖風(fēng)(音),一位在苯胺廠隔壁乙醇廠里工作的35歲電工稱,上個月廠里的化學(xué)檢測儀壞了五六次,工人們不得不疏散。
24 、Azobenzene was prepared with aniline and nitrobenzene as raw materials,potassium hydrate as catalyst and dimethyl sulforide as solvent.The yield was 69.23%.───在二甲亞砜溶劑中,以氫氧化鉀為催化劑,苯胺和硝基苯反應(yīng)得到偶氮苯,產(chǎn)率為69.23%。
25 、Methods: The target compound was synthesized using substituted aniline as starting material by condensation, hydrolysis and oximation.───方法:以取代苯胺為起始原料,通過縮合、水解、肟化反應(yīng)獲得目標(biāo)化合物。
26 、It has been tried to use the solvatfon to explain the ASIS effect of benzene on N,N-dimethyl aniline.───嘗試用溶劑化作用解釋了苯對N,N-二甲基苯胺的ASIS效應(yīng)。
27 、A method was developed for the determination of nitrobenzene in aniline by differential pulse polarography .───建立了測定苯胺中微量硝基苯的差式微分脈沖極譜法。
28 、In electroless polymerization,aniline molecules were oxidized to form Pn film by soluble oxygen on the catalytic surface of Pt or Pd substrate without the supply of electric current.───在沒有外電流的情況下,溶液中的苯胺分子在具有催化活性的鉑或鈀基底表面上被溶解氧氧化為聚苯胺膜。
29 、The degradation velocity of TOC is lower than that of aniline.───TOC降解速率低于苯胺分子降解速率
30 、In the reaction, some aniline is completely oxidized to CO2 or partially oxidized to carboxylic acid.───在反應(yīng)中有一部分苯胺被完全氧化或部分氧化成CO2或羧酸,
31 、Bromoethyl 2(H) quinolinone was synthesized by the acylation of aniline with biketene in toluene, the bromination in chloroform, and the cyclization in sulfuric acid.───以苯胺為原料,經(jīng)雙乙烯酮在甲苯中?;?***苯胺;在氯仿中溴化得溴****苯胺;
32 、The granulation of aerobic sludges for high-rate biodegradation of organic wastewater containing aniline and chloroanilines was investigated in a laboratory-scale sequencing airlift bioreactor (SABR).───以序批式氣提生物反應(yīng)器(SABR)為平臺,研究了苯胺和氯苯胺類有毒有機(jī)廢水處理過程好氧污泥顆粒化。
33 、This paper introduces the reaction mechanisms,process and result from reacting the HFA with phenol,aniline and cresol.───介紹了六氟丙酮與苯酚、甲基酚和苯胺的反應(yīng)機(jī)理、過程和結(jié)果。
34 、Using the parameters which were obtained by ab initio HF (STO-3G) MO method, the mechanism of the reaction of t-butyl hydroperoxide (BHP) with N, N-dimethyl aniline (DMA) was discussed.───本文由從頭算Hartree-Fock(STO-3G)MO法來探討叔丁基過氧化氫(BHP)與N,N-二甲苯胺(DMA)的反應(yīng)機(jī)理。 該反應(yīng)是由如下三種反應(yīng)組成的。
35 、In this paper the degradation of Polyaniline in the processof electrochemical polymerization of aniline was studied employing cyclic voltammetry methods and UV absorption spectra.───本文應(yīng)用循環(huán)伏安法和紫外吸收光譜對苯胺電化學(xué)聚合過程中聚苯胺的降解進(jìn)行了研究。
36 、What is driving the growth of Chinese aniline and nitrobenzene production?───是什么推動了中國苯胺和硝基苯生產(chǎn)的增長呢?
37 、Dichlorofluorobenzene is prepared by diazotizating of 2,4-dichloro aniline and substituting of 2,4-dichloro diazo benzene with fluorinion.───在此概述了由2,4-二氯苯胺經(jīng)過重氮化、置換制得2,4-二氯氟苯的生產(chǎn)新工藝,產(chǎn)品純度達(dá)到99。
38 、We predicted Rf value of phenol and aniline derivatives by this method, and compared it with classical algorithms such as forward selection,backward elimination, and stepwise procedure....───同時,與前進(jìn)選擇法、后退剔除法和逐步回歸法幾種傳統(tǒng)方法進(jìn)行了比較,得到了有啟示性的結(jié)果。
39 、The effect of three aniline derivatives with similar structure and different carcinogenic/mutagenic potency on immunologic function of BARB/C mice was investigated.───本項研究選用三種化學(xué)結(jié)構(gòu)相似,致癌/致災(zāi)變強(qiáng)度不同的苯胺衍生物處理BARB/C小鼠,然后對其進(jìn)行免疫學(xué)檢測。
40 、Abstract: The plasma polymerization of aniline in a capacitivity coupled of glow discharge was described and suitable conditions for plasma polymerization were found.───摘要: 應(yīng)用外部電容耦合式等離子體聚合裝置,研究了苯胺等離子體聚合規(guī)律,找到了最佳的聚合條件。
41 、It is insoluble in carbon disulphide, soluble in hot aniline and phenol.───它不溶于二硫化碳,溶于熱苯胺和苯酚。
42 、Some tire manufactures at home and abroad hope NCP improve RD's quality, for example Michelin demanded that isopropyl bis aniline must be less than 0.4% in its purchasing specification.───國內(nèi)外一些大型輪胎生產(chǎn)企業(yè)都要求本廠不斷提高防老劑RD的內(nèi)在質(zhì)量,如米其林公司在其采購指標(biāo)中明確要求伯胺含量必須低于0.4%。
43 、The aniline burns so hot that the cleanup crew can't get to the leak source.─── 苯胺燃燒太劇烈 救火人員無法接近泄漏源
44 、Several methods of introducing sulfonic groups via copolymerization with sulfonated aniline are elaborated in detail.───總結(jié)了由磺化苯胺單體的共聚合引入磺酸基團(tuán)的幾種方法。
45 、Using aniline and maleic anhydride as materials,the N -phenylmaleinmide is prepared with two-step method,and the appropriate reaction conditions are determined. The yield is up to 90%.───以苯胺和順丁烯二酸酐為原料,采用兩步法制得了N-苯基馬來酰亞胺,并確定了較佳的反應(yīng)條件,產(chǎn)品收率達(dá)90%.
46 、The quake caused a crack in a tank that was holding a severely toxic, highly flammable chemical called aniline.─── 地震導(dǎo)致儲罐裂縫泄漏 罐里裝的是劇毒的 極易燃化學(xué)品 苯胺
47 、Description of using 0.25% aniline solution to absorb phosgene in the atmosphere, and analyzed 1,3-diphenylurea formed with high pressure liquid chromatography (HPLC) were presented.───報道了用0.25%的苯胺溶液吸收大氣中的光氣,所形成的1,3-二苯基脲衍生物以高效液相色譜分析。
48 、The reaction rate constants of each basic reactions of indole formation horn aniline and glycol are calculated horn 300K to 1000K using TST method.───摘要用TST方法計算了從300K到1000K溫度下,苯胺和乙二醇生成吲哚的各反應(yīng)通道中各基元反應(yīng)的速率常數(shù)。
49 、By the deoxidization of zero-valent iron,nitrobenzene,an organic compound hard to be biodegraded,can be deoxidized to nitrosobenzene,and further to aniline,which is easily biodegraded.───利用零價鐵的還原性質(zhì),將難生物降解的有機(jī)物硝基苯先還原生成亞硝基苯,然后再進(jìn)一步還原成可生物降解的苯胺。
50 、The recovery of 2, 6-disubstituted aniline can be over 70% and the enviroment can not be polluted using the route of imidazolidinyl-kelone.───咪唑烷酮路線,不僅收率高達(dá)70%以上,而且對環(huán)境友好。
51 、Electromagnetic wave shielding fabric was prepared by in-situ chemical polymerization of aniline in the presence of cotton substrate, using hydrochloric acid as the doping agent and ammonium persulfate as the oxidant.───摘要以鹽酸為摻雜劑,過硫酸銨為氧化劑,在棉織物表面采用現(xiàn)場吸附聚合法生成一層導(dǎo)電聚苯胺,由此設(shè)計出一種具有良好電磁屏蔽效能的織物。
52 、A clean process for synthesizing fluobenzene with aniline was developed.───開發(fā)了以苯胺為原料的氟苯清潔生產(chǎn)工藝。
53 、From highly Pare m-trifluoromethyl aniline, the Flutamide is prepared by acylation with isobutyl chloride and nitration with assistant S.───以高純度間三氟甲基苯胺為原料,經(jīng)異丁酰氯?;?,再在助劑S存在下進(jìn)行硝化制得氟他胺。
54 、Reaction of HFA with phenol and aniline───六氟丙酮與苯酚和苯胺的反應(yīng)
55 、The amidation and esterification of different cyclic anhydrides with aniline and phenol gave different major products, and the routes were optimized.───摘要研究了環(huán)酐與苯胺和苯酚的酰胺化及酯化反應(yīng),優(yōu)化了酰胺化及酯化反應(yīng)條件。
56 、The results showed that the degradation and removal of aniline, naphthalene and indene were highly related to their water solubility and volatility.───典型芳烴類物質(zhì)苯胺、茚和萘在好氧條件下的降解和去除與其水溶性和揮發(fā)性密切相關(guān)。
57 、Similar to the mechanism of electroless plating,electroless polymerization of aniline involves local and spontaneous electrochemical reactions on only substrate.───與化學(xué)鍍的原理類似,苯胺的無電聚合反應(yīng)過程包含陰極半反應(yīng)和陽極半反應(yīng)兩個電化學(xué)反應(yīng)。
58 、Of course aniline's alternate use had to be jet fuel.─── 當(dāng)然了 苯胺還可用作噴氣機(jī)燃料
59 、The uptakes of aniline and PCP by clay-HDTMA result in partition mechanism demonstrate a noncompetitive adsorption behavior.───在雙溶質(zhì)吸附試驗結(jié)果顯示,有機(jī)黏土對苯胺及五氯酚之機(jī)制為分配作用,且證明無競爭吸附之現(xiàn)象發(fā)生。
60 、So,aniline is the most effective corrosion inhibi...───根椐實驗可以認(rèn)為,苯胺是理想的酸洗緩蝕劑。
61 、However, when the pH rises to a certain value, the degradation rate of aniline will drop.───但當(dāng)pH值升到一定程度以后,去除率又有所下降。
62 、N, N-dimethyl-P-toluidine (DMT) was compared to N, N-dimethyl aniline (DMA) as cure reaction promoters for an unsaturated polyester resin anchor agent.───摘要研究了過氧化物與芳叔胺N,N-二甲基苯胺(DMA)和N,N-二甲基對甲苯胺(DMT)組成的體系引發(fā)不飽和聚酯錨固劑的固化,兩種促進(jìn)劑的錨固力和壓縮強(qiáng)度相當(dāng);
63 、The results showed that the immobilized cyclodextrin adsorbed phenol and aniline mainly via physical adsorption, while adsorbed metal ions via chemical adsorption.───實驗結(jié)果表明:固載化環(huán)糊精對苯酚和苯胺的吸附主要是物理吸附,對金屬離子以化學(xué)吸附為主。
64 、A possible pathway of aniline degradation by O3 is given.───提出了O3降解苯胺的可能途徑。
65 、Based on the situation of aniline production and consumption at present and in the next two years in China,some development proposals in aniline production are put forward.───根據(jù)目前和未來兩年內(nèi)我國苯胺的生產(chǎn)和消費(fèi)狀況,提出了我國苯胺生產(chǎn)的發(fā)展建議。
66 、The contents of phenol and aniline in refinery waste water were simultaneously determined by Kalman filtering UV-spectrophotometry with satisfactory result.───摘要用卡爾曼濾波紫外分光光度法同時測定了模擬煉油廢水中苯酚和苯胺的含量,取得了滿意的結(jié)果。
67 、A possible degradation pathway of aniline by O3 is obtained on basis of the experimental results.───并根據(jù)實驗結(jié)果得到了臭氧氧化降解苯胺的降解途徑。
68 、ZHANG Wenwei,XIN Changbo,LI Xiaohui,et al.Direct determination of phenol and anilin in environmental water by fluorescenc spectrophotometry[J].Chinese Journal of Analysis Laboratory,2000,19(5):37-39.───[7]張文偉,辛長波,李曉輝,等.熒光光度法直接測定環(huán)境水中的苯酚和苯胺[J].分析試驗室,2000,19(5):37-39.
69 、In the SEM images, it's found that the composites have the similar figure structure to SF coal, which shows that the aniline is polymerized in the templet of SF coal.───SEM分析發(fā)現(xiàn),SF煤/聚苯胺復(fù)合物顆粒外型與SF煤相似,這表明聚苯胺是以SF煤為模板聚合的;
70 、Polyaniline, which is polymerized in the mesoporous channels by the filling of aniline monomers, binds to mesoporous silica to form the composites of mesoporous silica and polyaniline.───引入苯胺單體后在孔道內(nèi)聚合生成聚苯胺,即聚苯胺與有序介孔二氧化硅形成了復(fù)合物。
71 、Recent studies show that developer and farming reagent can be availed if aniline derivative, for example, methyl aniline etc.───此外,苯胺還可以用作溶劑和其它化工原料。
72 、Aniline, which not only dissolves in water at low ratio but ethanol, aether and benzene at any ratio as well, can take part in halogenating and diazoing reaction.───有堿性,能與鹽酸(或硫酸)反應(yīng)生成鹽酸(或硫酸)鹽;
73 、The advanced nitration technology and hydrogenation technology are discussed. The aniline production quantity is explained.───介紹了苯胺生產(chǎn)中先進(jìn)的硝化技術(shù)、還原技術(shù);闡述了國內(nèi)外苯胺的生產(chǎn)情況。
74 、The purpose of polymethylene polyphenyl polyamines purification system is to get rid of anilin and water.The stripping tower and drying tower are two main separation units in the system.───多胺精制系統(tǒng)的任務(wù)是脫除粗多胺中的苯胺和水,針對現(xiàn)有工藝存在的精制效果差、消耗高等問題,分別對影響汽提塔和干燥塔的因素進(jìn)行了模擬分析,提出了相應(yīng)的改進(jìn)措施。
75 、An early name for rotary letterpress printing with rubber plates and fluid, fast-drying inks that contained dyes derived from aniline oils. See also: flexography.───中義以橡膠版及快乾墨印制的輪轉(zhuǎn)凸版印刷品早期的名稱,因印墨中含有苯胺油。參見樹脂凸版。
76 、Though the capacity of aniline and nitrobenzene has been in surplus since the end of 2006, many new installations of aniline and nitrobenzene are still under construction or to be constructed.───盡管自 2006 年底以來苯胺和硝基苯的生產(chǎn)能力已經(jīng)處于過剩,許多新的苯胺和硝基苯裝置仍然正在建設(shè)或者將要開工。
77 、But now, the gap is shrinking, and China's aniline market has become complicated and inconstant.───但是現(xiàn)在,這個差距正在縮小,而且中國的苯胺市場已經(jīng)成為復(fù)雜多變的。
78 、The present research analyzed the structure of the condensation products of aniline with acetone by GC-MS.───本文利用GC-MS對苯胺與丙酮縮合反應(yīng)的產(chǎn)物進(jìn)行了結(jié)構(gòu)分析。
79 、The photodegradation rate constants and the half-lives of phenol and aniline in the water of the Second Songhua River were determined by means of outdoor simulation experiments.───摘要利用室外模擬實驗測定了苯酚和苯胺光降解的速度常數(shù)和半壽命。
80 、Products containing aromatics or naphthenes have lower aniline points than products containing paraffins.───含有芳烴和環(huán)烷烴的產(chǎn)品比含有石蠟的產(chǎn)品的苯胺點(diǎn)相對要高。
81 、Besides the action of conduction anesthesia,chlordimeform has the cardiovascular toxicity and the antiarrhythmic action induced by barium chloride,parallel to 2,6-dimethyl aniline.───殺蟲脒有局部**作用,殺蟲脒和利多卡因的代謝物2.6-二甲基苯胺都有心血管毒性和抗氯化鋇誘發(fā)的心律失常作用。
82 、The structure of 3-(9-acridinylamino)-5-(hydroxymethyl)aniline( AHMA)-an antitumor drug derived from the clinically used antileukemia drug m-AMSA was analyzed by x-ray crystallography.───本文用X射線晶體衍射法分析了抗癌藥物3-吖啶氨基-5羥甲基苯胺(3-(9-acridiny-lamino)-5-(hydroxymethyl)aniline,AHMA)的分子結(jié)構(gòu)。 AHMA的化學(xué)式為C_(20)H_(17)N_3O,Mr=315.37。
83 、Derived from aniline.───從苯胺派生的
84 、Two kinds of curing method have been researched and the optimum conditions using for adsorption porcelain clay and CTS-modified porcelain clay for adsorption of aniline were investigated in detail.───它們對處理廢水中的苯胺具有吸附率高、工藝簡單、操作方便、生產(chǎn)成本低等特點(diǎn)。對處理環(huán)境水樣中的苯胺污染物具有較好的應(yīng)用價值。
解熱鎮(zhèn)痛藥的苯胺類
苯胺類(Anilines)衍生物中,以非那西?。╬henacetin)使用最早,但因毒性大,除少數(shù)復(fù)方制劑還應(yīng)用外,均為其活性代謝產(chǎn)物對**氨基酚(acetaminophen,又名撲熱息痛,paracetamol)取代,acetaminophen是目前應(yīng)用量最大的解熱鎮(zhèn)痛藥物之一.
對**氨基酚Acetaminophe
藥理作用及臨床應(yīng)用
Acetaminophen解熱鎮(zhèn)痛作用與aspirin相當(dāng),但抗炎作用極弱.因此臨床僅用于解熱鎮(zhèn)痛.但acetaminophen無明顯胃腸刺激作用,對不宜使用aspirin的頭痛,發(fā)熱患者,適用本藥.
體內(nèi)過程口服易吸收,0.5 1h達(dá)到最大血藥濃度.在常用臨床劑量下,絕大部分藥物在肝臟與葡萄糖醛酸和硫酸結(jié)合為無活性代謝物,t1/2為2 4h.較高劑量時,上述催化結(jié)合反應(yīng)的代謝酶飽和后,藥物經(jīng)肝微粒體混合功能氧化酶代謝為對**苯醌亞胺.**苯醌亞胺是一個有毒的代謝中間體,可與谷胱甘肽(glutathione)結(jié)合而解毒.長期用藥或過量中毒,體內(nèi)谷胱甘肽被耗竭時,此毒性中間體以共價鍵形式與肝,腎中重要的酶和蛋白分子不可逆結(jié)合,引起肝細(xì)胞,腎小管細(xì)胞壞死.
不良反應(yīng)與注意事項Acetaminophen為非處方藥.偶見皮膚黏膜過敏反應(yīng).長期使用極少數(shù)患者可致腎毒性,如腎乳頭壞死和慢性間質(zhì)性腎炎等.過量誤服(10 5g以上),可致急性中毒性肝壞死.
藥物相互作用 ① Aniline與肝藥酶誘導(dǎo)藥如巴比妥類合用時,易發(fā)生肝臟毒性反應(yīng);② Aniline可延長氯霉素(chloramphenicol)的半衰期,并增加其毒性.
**苯胺的制備
在氮?dú)?0℃下向氫化反應(yīng)器中加入15份乙酸鈉,60份NaHCO3,1320份MeOH和1015份1-氯-2,4-二硝基氯苯,加入11份1%PtC,加入0.15份NH4VO3和66份水。
氫化在60℃和18巴下進(jìn)行。分離產(chǎn)物為3-氨基-4-氯-苯胺(785份,理論值的85%)。3-氨基-4-氯**苯胺與醋酸反應(yīng)制得3-氨基-4-氯**苯胺。
其中重要的是形成的羥胺中間體,芳基羥胺也被稱為強(qiáng)致癌物,因此在中斷或不完全氫化的情況下構(gòu)成高危險潛力。因此需要選擇一種雜質(zhì)少,產(chǎn)率高的制備方法。
擴(kuò)展資料:
注意事項:
1、苯胺有毒,它能經(jīng)皮膚被吸收,使用時要注意安全。
2、加鋅粉的目的,是防止苯胺在蒸餾時被氧化,通常只要少量即可,加得過多,因為被氧化的鋅生成氫氧化鋅為絮狀事物會吸收產(chǎn)品。
3、反應(yīng)時分餾溫度不能太高,以免大量乙酸蒸出而降低產(chǎn)率,選擇較短的分餾柱,可以避免反應(yīng)溫度過高。
4、不可以用過量的水處理**苯胺,經(jīng)實驗數(shù)據(jù)表明**苯胺在水中的含量為5.2%時,重結(jié)晶效果最好,**苯胺重結(jié)晶產(chǎn)率最大。
百度百科-**苯胺
百度百科-加氫反應(yīng)器